ZCURVE_CoV Database Open to the World

ZCURVE_CoV Database developed by Tianjin University BioInformatics Centre (TUBIC) is absorbed into the National Genomics Data Center and open to the world.

In face of the quick spread of COVID-19 epidemic, scientists are all making every minute and second count to fight against the virus and devote themselves into the development of the medicines to prevent and control it.

Prof. Gao Feng and Dr. Luo Hao from TUBIC have made gene recognition and proteinase cleavage sites prediction for more than 2000 coronavirus, including COVID-19, given the present situation that a large portion of complete genome sequences of COVID-19 published on the US NCBI lack the detailed genome annotation, especially the annotation of the cleavage sites of polyprotein.

The results are fed into the ZCURVE_CoV Database (an updated database of annotated protein-coding genes and proteinase cleavage sites in thousands of coronavirus genomes), which is expected to provide scientific basis for the research on genome structure, gene function, origin and variation of new coronavirus and drug research and development. This database is available online athttp://tubic.tju.edu.cn/CoVdb,http://tubic.org/CoVdb/, and can also be accessed on National Genomics Data Center website (https://bigd.big.ac.cn/) through cross-database retrieval.

It is reported that ZCURVE_CoV was first developed by TUBIC under the leadership of Prof. Zhang Chunting, an academician of the Chinese Academy of Sciences during SARS epidemic.

By the School of Science

Editor: Eva Yin